The EZbakR-suite
Summary
- Introduced Snakemake pipeline (fastq2EZbakR) and R package (EZbakR)
- Generalizes feature assignment: the set of annotated genomic features that you can perform analyses on.
- Generalizes mixture modeling: how the fraction of reads from labeled RNA are estimated.
- Generalizes dynamical systems modeling: how kinetic parameters are estimated from NR-seq data.
- Generalizes comparative analyses: how kinetic parameters are compared across biological conditions.
Link to preprint
bakR
Summary
- Introduced an R package (bakR) designed to compare RNA synthesis and degradation rate constants across biological conditions.
- Also introduced a hierarchical modeling strategy to increase statistical power of these comparisons.
Link to paper
